Your ultimate armor against aging—all the way down to the cellular level

Wouldn’t you love to be able to keep all the wisdom, knowledge, and skills you’ve earned through the years—but without giving up the health and vitality you enjoyed in your youth?

I know I would.

Who doesn’t yearn to live a good, long life, without health-related complications? There’s a reason “anti-aging medicine” is at the forefront of alternative health.

Unfortunately, anti-aging medicine is such a popular field that it attracts a lot of “experts” who are just out to make a quick buck. Which means they’re often selling hype and pseudoscience instead of providing real help.

But the fact is, aging is a complex topic that involves an entire interconnected web of body processes. It’s not something you can grasp—let alone try to change—without an in-depth understanding of medicine. True anti-aging medicine requires expertise in how all the different aging processes work together. And to do it right, you need to stay on top of the latest research.

That is, if you’re looking to make real, lasting changes—and not just provide a quick fix.

Now don’t get me wrong. There are a few simple anti-aging approaches that can have a reasonable impact. Hormones, for example. Whether it be testosterone, estrogen, progesterone, human growth hormone, or all of them, hormones can work against some aging processes. Same for some medications, like metformin, which controls blood sugar and seems to cast a longevity effect on those who take it. I’m a proponent of both of those, when appropriate.

But anti-aging goes deeper than just hormones or medications. To effect real change, I am much more guided by a goal of promoting healthy aging from the inside out (through cells)—not the outside in. That’s always been my philosophy when it comes to aging better.

The reason? Because without healthy cells, there is no such thing as a healthy body. It’s that simple. And the enemy of healthy cells is oxidative stress. So that’s my first target in stemming or reversing age-related damage.

Nature’s best oxidative stress buster

Sometimes when I talk about oxidative stress (and how detoxification counters it), I see people’s eyes glaze over. Which is understandable. It’s a complicated topic. But here’s a very simple metaphor that I think describes it well.

If you think of your body as a machine, your cells are the parts that make it work. Oxidative stress is akin to the rust on the outsides of those parts (your cell membranes, in this case). Just as with a machine, if you have rust, you need to combat it and keep it from getting worse.

That’s where WD-40 comes in. It helps clean away the damage that’s already been done and protect against future corrosion.

And it turns out that nature has its own version of WD-40. It’s called glutathione. It’s what helps cells rid themselves of oxidative damage and prevent it from happening in the future.

Glutathione is such a powerful detoxifier that it has earned a special title among some natural health experts, who refer to it as “the mother of all antioxidants.”

Glutathione plays a role in virtually all detoxification reactions in the body. It helps neutralize and eliminate toxins from chemical preservatives, agricultural pesticides, heavy metals, alcohol, and both over-the-counter and prescription drugs.

In addition to regulating detoxification in the trillions of cells throughout the body, glutathione is vitally important to liver function. That’s essential, since the liver is our primary organ of detoxification.

As our armor against the toxic stresses of everyday life, glutathione is a critical line of defense against aging. But, as with most good things, levels decline with age. And that sets the stage for a wide range of age-related health problems.

So why isn’t everyone taking glutathione supplements?

Well, unfortunately, it’s not that simple.

Getting to the root of glutathione production

Until now, there really hasn’t been a good way of increasing your body’s levels of glutathione. When it’s taken orally—even in liposomal form, with good absorption—the body just doesn’t make good use of it. That’s why complementary medical doctors often offer it intravenously in their offices. And while it’s effective, it’s not always affordable or convenient, long-term.

Which is why I’ve been advising my patients for years to instead get to the root of glutathione production in the body, and to work to increase it. Instead of supplementing with glutathione, they’re supporting their body’s ability to produce it on its own—and to retain it after it’s been produced.

The way I’ve had them do that is by recommending a precursor to glutathione called N-acetyl-cysteine, or NAC. It’s been effective, but I’ve recently come across an even more impressive way of increasing glutathione production.

I’ll tell you about that new discovery in just a minute. But first, I want to tell you about some research that just came out talking about this way of approaching glutathione production.

The study, published in the journal Redox Biology, looked at how to maintain glutathione levels and prevent the routine metabolic declines associated with aging. I won’t get too far into the weeds (remember what I said about eyes glazing over?), but here’s a short version.

The researchers confirmed what we already know about glutathione: that it helps protect against daily toxic assaults, but its levels decline as we age. And reduced glutathione puts us on the road to age-related health problems. Part of the reason is that the glutathione in older cells depletes more rapidly, causing the cells to die off twice as fast when exposed to stress.

Then the researchers looked at NAC, which already has a use in conventional medicine as an emergency detoxifier. In cases of acute exposure to toxins (such as ingesting poison), high doses of NAC are administered. But the researchers found that at lower levels, NAC can help to deal with everyday toxins, by keeping glutathione levels up and preventing age-related metabolic decline.

And that may hold promise in preventing cardiovascular disease, cancer, and other illnesses that have been linked to age-related decline.

In the study, preventive treatment with NAC increased glutathione levels and helped prevent the rapid cell death I mentioned.

So the research backs up the general approach I’ve been taking for years. If you want to boost glutathione, don’t supplement it. Just help your body produce more of it.

That leads me to the development I am so excited to tell you about. It’s a new way to boost glutathione production. Not only that, this approach also allows your body to hang onto the glutathione it produces for much longer.

The answer is in a new probiotic strain called Lactobacillus fermentum, or ME-3.

ME-3’s 1-2-3 punch

ME-3 boosts glutathione levels in three different ways: First, it synthesizes glutathione. Second, it extracts glutathione from the surrounding environment. And third, it recycles oxidized glutathione back to its active or “reduced” form.

But ME-3’s benefits go beyond glutathione production. Research has found that ME-3 has (at least) eight other key benefits as well:

  1. Produces manganese superoxide dismutase (Mn-SOD), an antioxidant that specifically helps protect mitochondria from free radical damage
  2. Regenerates other antioxidants, like vitamin C, vitamin E, and coenzyme Q10
  3. Lowers LDL cholesterol and decreases the oxidative damage it causes
  4. Promotes liver and cellular detoxification
  5. Has antibacterial activity against various strains of harmful bacteria
  6. Protects and improves gut barrier function
  7. Reduces local and systemic levels of inflammation
  8. Increases activity of enzymes that detoxify organophosphates (OPs)—widely used agricultural pesticides linked to lower IQ, autism, and attention deficit hyperactivity disorder

Now that is a supplement I would want to take myself every day. (In fact, it will definitely be earning a spot on the 2018 edition of my Desert Island Supplement List.) And I’m already seeing better results in my patients than I’ve ever seen from my old glutathione-boosting regimen using NAC.

When you have a supplement that can do so much from the inside-out, you’re talking about true anti-aging medicine.

ME-3 is available as a product called Reg’Activ. I recommend 60 mg of the “Immune & Vitality” formula per day.  You can order this product by phone at 1-972-255-3918, through the distributor’s website:, or purchase in-store at most Whole Foods and The Vitamin Shoppe locations.



Don’t forget the tried-and-true detox

While we’re on the subject of getting rid of toxins, don’t forget my tried-and-true detox advice. Nearly everyone can benefit from a periodic detox, like the one I outline in The A-List Diet. (If you don’t have a copy yet, you can pick one up in your local bookstore or by visiting

Regular detoxes help clear out the toxins that inevitably accumulate in your body from day-to-day living and exposure to unavoidable things like air pollution, cleansers, etc. They also set your body up to successfully meet and defend against any toxic challenges that lie ahead.

And that should be the goal of every true anti-aging plan. (For a detailed plan of safe detoxing, refer to the September 2013 issue of Logical Health Alternatives.)



“Boosting levels of known antioxidant may help resist age-related decline,” ScienceDaily (, 10/24/16

“Glutathione maintenance mitigates age-related susceptibility to redox cycling agents,” Redox Biology 2016; 10: 45-52